Referencing obscure Internet memes in mainstream media almost invariably falls flat, but if movie!Deadpool walked into the aftermath of a scene of gratuitous carnage and quipped “wow, it looks like a children’s hospital in here” it would totally work. To those who don’t catch the reference it would come off as generic edgy bullshit, and to those in the know, Deadpool having a Tumblr account is completely believable.
