with why my adderall was having such uneven effects and varying efficacy
and the weird pattern of what made it work and not work and if it was building up in my system or not
and fucking nobody told me I shouldn’t drink a glass of Kool-Aid to take the pills with
or eat fucking Pop-Tarts or Life cereal
this is the most useful information I have ever received from tubr and it seems to be confirmed by several other places upon searching
so this actually should be spread like wildfire like actually
Me reading this realizing tunglr dawt kom gave me more information about my medication than MYDOCTORRRRRSSSSSS MYYYYYYYY FUCKENNNNN DOCTORSSSSS PLURAL MULTIPLE DOCTORSSSSSSSS
Reblogging to spread this ridiculously important info
Generally speaking, your doctors actually may not know these things. This is the kind of stuff to ask your pharmacist about.
Are. You. Kidding. Me. I’VE BEEN STRUGGLING WITH MY ADHD MEDS NOT WORKING SOMETIMES AND THIS IS WHY???????
well fuck
Chaotic Evil Me: Using antacids has the reverse effect.
Source: I used to rail those mfs
Also: from the Introduction section of this study. I had to cite the introduction because it’s the last part of it that I understand. I don’t think this was tested in a living human person, it’s like dog kidney cells and a blood/amphetamine mixture that they put through an Ultra-centrifuge at 435,000 Gs. Science is crazy.
“For example, when urine pH decreased from alkaline (pH ≈ 7.5–8.5) to acidic (pH ≈ 4.5–5.5), the amount of drug excreted unchanged in urine for weak bases, such as pethidine, methamphetamine, and mexiletine, increased up to 21-fold (Chan, 1979), 48-fold (Beckett and Rowland, 1965c), and 87-fold (Kiddie et al., 1974), respectively, whereas the renal clearance of weak acids, such as chlorpropamide (Neuvonen and Kärkkäinen, 1983) and salicylic acid (Macpherson et al., 1955), decreased by 99% and 97%, respectively… This demonstrates that the magnitude of urine pH effect on plasma AUC could be as significant as drug-drug interactions resulting from coadministration with a strong inhibitor or inducer.”
This probably wasn’t my original source for the pH thing though, cuz it’s been like 15 years since I heard about this
