Normally, Calico cats should only be female, however one in three thousand Calico cats are actually male. This is because they have Klinefelter Syndrome, an intersex genetic condition. In cats, colour is stored on the x chromosome, a three coloured Calico has to have 2 X chromosomes, plus white. Males usually only have one X, unless they have Klinefelter Syndrome, where you have two X’s and one Y.
Furries are quick to point out that male Calico cat fursonas wouldn’t exist, but they actually would, they’d just be rare. Klinefelter Syndrome also occurs in humans of course. (I know this first hand.)
Therefore I propose: Calico Catboys COULD be real, despite what the furry meme says, however if they followed the human characteristics of Klinefelter Syndrome, they would be taller than average, usually over 6 feet, have a feminine weight distribution, including some limited breast growth, have a feminine hair/fur growth pattern, and have around a 20% chance of being autistic.